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	Provedor de dados BJMBR (1) Autor Chen,Yan (1) Wang,Jinjun (1) Zheng,Yu (1) Zhou,Zhihong (1) Palavra-chave Anti-inflammatory effects (1) Baicalein (1) Lipopolysaccharide (1) MAPK pathway (1) NF-κB pathway (1) Tubular-interstitial nephritis (1) Mais... Tipo do documento Info:eu-repo/semantics/article (1) Ano 2018 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Baicalein alleviates tubular-interstitial nephritis in vivo and in vitro by down-regulating NF-κB and MAPK pathways BJMBR Chen,Yan; Zheng,Yu; Zhou,Zhihong; Wang,Jinjun. Tubular-interstitial nephritis (TIN) is characterized by tubular cell damage and inflammatory lesions of kidneys. Baicalein (BAI) is a flavonoid compound found in the roots of Scutellaria baicalensis Georgi. The present study was undertaken to explore the anti-inflammatory and anti-oxidative effects of BAI on TIN patients and a lipopolysaccharide (LPS)-induced TIN cell model. The expression levels of interleukin-6 (IL-6), IL-10, and tumor necrosis factor α in serum samples of TIN patients and culture supernatants of renal proximal tubular epithelial cells (RPTECs) were evaluated using enzyme-linked immunosorbent assay. Creatinine clearance was calculated using the Cockcroft-Gault equation. Activities of malondialdehyde, superoxide dismutase, and... Tipo: Info:eu-repo/semantics/article Palavras-chave: Tubular-interstitial nephritis; Baicalein; Lipopolysaccharide; Anti-inflammatory effects; NF-κB pathway; MAPK pathway. Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018001000606 Registros recuperados: 1 Primeira ... 1 ... Última

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